Table 3 Neurophysiological factors in the models after Lasso regression.

From: Associations among neurophysiology measures in irritable bowel syndrome (IBS) and their relevance for IBS symptoms

Neurophysiological factor

GSRS-IBS

Pain

Bloating

Constipation

Diarrhoea

Satiety

Total

HAD

X

X

X

X

X

X

Colonic transit time

  

X

 

X

 

Early rectal tone response

      

Late rectal tone response

      

Rectal dynamic compliance

      

Rectal static compliance

      

Rectal first sensation threshold

  

X

   

Rectal pain threshold

X

X

 

X

X

X

SI phase III time

  

X

   

SI fasted contraction frequency

  

X

   

SI fed contraction frequency

      

SI potential difference, mean

 

X

X

 

X

 

SI potential difference, max

  

X

   

SI potential difference, rate of rise

   

X

  

Baroreceptor sensitivity

 

X

X

   

Baroreceptor effectiveness

      

RMSE of Lasso score

1.16

1.27

1.56

1.18

1.23

0.85

RMSE of overall score

1.24

1.40

1.64

1.27

1.48

0.89

Correlation with Lasso score

0.38

0.20

0.14

0.29

0.29

0.40

Correlation with overall score

0.21

0.23

0.10

0.16

0.13

0.25

  1. Neurophysiological factors in the models after Lasso regression in GSRS-IBS total score and domain scores of GSRS-IBS. Lower RMSE indicates lower variability and thus better predictive ability of the model. Correlations are stated as Spearman’s rho. For comparison, the correlations with the overall neurophysiology score are included.
  2. GSRS-IBS: Gastrointestinal Symptom rating scale, IBS version; HAD: Hospital Anxiety and Depression scale; Lasso: Least Absolute Selection and Shrinkage Operator regression; overall: Neurophysiology scores derived from all 16 neurophysiological factors; RMSE: Root Mean Square Error; pain threshold: pressure threshold for pain during the balloon distension test of rectal sensorimotor function; SI: small intestine/intestinal.
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