Figure 4 | Scientific Reports

Figure 4

From: Robust combination of liver stereotactic body radiotherapy modulates pharmacokinetics of sorafenib toward preferable parameters

Figure 4

Effects of irradiation on the CYP3A4 protein expression level. CYP3A4 activity was increased significantly by the sequential RT2Gy and RT9Gy regimens compared with the concurrent RT2Gy and RT9Gy regimens of RT. Moreover, compared with RT2Gy, RT9Gy significantly increased CYP3A4 activity in the sequential regimen. The data are expressed as the mean ± SEM values (n = 5 per group) (p < 0.05: *p < 0.01: **p < 0.005: ***p < 0.001: ****).

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