Table 2 The comparison of clinical characteristics between cerebellopontine angle WNT- and SHH-medulloblastomas.

From: The clinical treatment and outcome of cerebellopontine angle medulloblastoma: a retrospective study of 15 cases

Characteristics

WNT (n = 5) No. of patients (%)

SHH (n = 10) No. of patients (%)

P*

Sex

Female

1 (20)

6 (60)

0.282

Male

4 (80)

4 (40)

 

Age at diagnosis

<18

1 (20)

2 (20)

1.000

≥18

4 (80)

8 (80)

 

Origin#

Cerebellum

0 (0)

9 (90)

0.002

Brainstem

5 (100)

1 (10)

 

Growth pattern

ICB/ICB + ECB

1 (20)

10 (100)

0.004

Only ECB

4 (80)

0 (0)

 

4th ventricle floor involvement

Yes

3 (60)

1 (10)

0.077

No

2 (40)

9 (90)

 

CN involvement

Yes

2 (40)

5 (50)

0.573

No

3 (60)

5 (50)

 

Cystic

Yes

3 (20)

6 (60)

1.000

No

2 (80)

4 (40)

 

Enhancement

Solid

5 (100)

3 (30)

0.026

Heterogeneous or minimal

0 (0)

7 (70)

 

Margin

Well-defined

4 (80)

4 (40)

0.282

Ill-defined

1 (20)

6 (60)

 

Hemorrhage/mineralization

Yes

1 (20)

4 (40)

0.600

No

4 (80)

6 (60)

 

Necrosis

Yes

1 (20)

7 (70)

0.119

No

4 (80)

3 (30)

 

Histology

CMB

5 (100)

7 (70)

0.505

DNMB

0 (0)

3 (30)

 
  1. Abbreviations: CMB, classic medulloblastoma; DNMB, desmoplastic/nodular medulloblastoma; ECB, extracerebellar; GTR, gross total resection; ICB, intracerebellar; CN, cranial nerve; STR, subtotal resection.
  2. *Fisher’s exact test (2-sided). #The putative point of origin of the tumor is identified based on the pre- and postoperative MRI results and intraoperative reports.
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