Table 3 Regression model of renal biomarkers predicted by the TWICL, 16 types of MT 1A and 2A SNP combination, and other potential confounders.
Serum creatinine (mg/dL) | Serum uric acid (mg/dL) | Urinary uric acid (mg/g Cr) | Urinary NAG (mg/g Cr) | |||||
|---|---|---|---|---|---|---|---|---|
ß (SE) | p-value | ß (SE) | p-value | ß (SE) | p-value | ß (SE) | p-value | |
Time-weighted ICL (μg/dL) | −0.0006 (0.0007) | 0.38 | 0.0081 (0.0053) | 0.13 | −0.054 (0.065) | 0.41 | 0.016 (0.0076) | 0.043 |
Group 1 | — | — | — | — | — | — | — | — |
Group 2 | 0.020 (0.042) | 0.63 | 0.48 (0.31) | 0.13 | −0.019 (3.83) | 1.00 | 0.010 (0.45) | 0.98 |
Group 3 | −0.0082 (0.045) | 0.86 | 0.40 (0.34) | 0.25 | 0.040 (4.14) | 0.99 | 0.30 (0.49) | 0.54 |
Group 4 | 0.079 (0.058) | 0.17 | 0.78 (0.44) | 0.076 | −1.90 (5.31) | 0.72 | 0.43 (0.62) | 0.49 |
Group 5 | −0.0032 (0.048) | 0.95 | 0.29 (0.36) | 0.42 | 12.47 (4.39) | 0.0047 | −0.17 (0.52) | 0.75 |
Group 6 | 0.012 (0.044) | 0.78 | 0.48 (0.33) | 0.15 | −13.52 (4.00) | 0.0008* | 0.030 (0.47) | 0.95 |
Group 7 | 0.030 (0.043) | 0.49 | 0.33 (0.32) | 0.31 | −9.20 (3.91) | 0.019 | 0.033 (0.46) | 0.94 |
Group 8 | 0.044 (0.078) | 0.57 | −0.12 (0.59) | 0.84 | 8.92 (7.16) | 0.21 | −0.33 (0.84) | 0.70 |
Group 9 | 0.0038 (0.052) | 0.94 | 0.14 (0.39) | 0.71 | −9.70 (4.74) | 0.041 | 0.45 (0.56) | 0.42 |
Group 10 | −0.076 (0.084) | 0.37 | −0.47 (0.63) | 0.46 | 3.94 (7.68) | 0.61 | −0.098 (0.90) | 0.91 |
Group 11 | −0.017 (0.084) | 0.84 | 0.65 (0.63) | 0.30 | 1.92 (7.64) | 0.80 | −0.19 (0.90) | 0.83 |
Group 12 | −0.0023 (0.042) | 0.96 | 0.53 (0.32) | 0.10 | −10.97 (3.87) | 0.0047 | 0.90 (0.45) | 0.047 |
Group 13 | 0.066 (0.078) | 0.40 | 1.20 (0.59) | 0.041 | 0.76 (7.12) | 0.92 | −0.44 (0.84) | 0.60 |
Group 14 | 0.020 (0.049) | 0.69 | 0.23 (0.37) | 0.54 | −1.55 (4.46) | 0.73 | 0.31 (0.52) | 0.56 |
Group 15 | −0.061 (0.064) | 0.34 | 0.21 (0.48) | 0.66 | 4.32 (5.89) | 0.46 | 0.54 (0.69) | 0.43 |
Group 16 | 0.030 (0.061) | 0.62 | 1.034 (0.46) | 0.025 | −8.33 (5.60) | 0.14 | 0.59(0.66) | 0.37 |
Gender(male) | 0.32 (0.021) | <0.0001 | 1.47 (0.16) | <0.0001 | −4.77 (1.94) | 0.014 | −0.74 (0.23) | 0.0013 |
Age (year) | −0.0002 (0.0010) | 0.88 | −0.012 (0.0077) | 0.11 | 0.033 (0.094) | 0.73 | 0.047 (0.011) | <0.0001 |
BMI (kg/m2) | 0.0011 (0.0024) | 0.65 | 0.099 (0.018) | <0.0001 | 0.46 (0.22) | 0.036 | 0.035 (0.026) | 0.17 |
Smoke | −0.032 (0.021) | 0.13 | −0.034 (0.16) | 0.83 | 1.87 (1.96) | 0.34 | 0.50 (0.23) | 0.031 |
Drink | 0.0070 (0.024) | 0.77 | 0.014 (0.18) | 0.94 | 1.17 (2.16) | 0.59 | 0.19 (0.25) | 0.45 |
Constant | 0.77 (0.072) | <0.0001 | 3.15 (0.54) | <0.0001 | 31.99 (6.58) | <0.0001 | −0.13 (0.77) | 0.8660 |
