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Figure 1

From: Inhibition of G protein-gated K+ channels by tertiapin-Q rescues sinus node dysfunction and atrioventricular conduction in mouse models of primary bradycardia

Figure 1

PP rate, heart rate and atrioventricular conduction in Cav1.3−/− and Cav1.3−/−/Cav3.1−/− mice under basal conditions. PP rate, heart rate and PR interval recorded in WT (black circle), Cav1.3−/− (red circle, (A–C) and Cav1.3−/−/Cav3.1−/− mice (orange circle, G-I), together with corresponding representative samples of telemetric ECG recordings (WT in (D), Cav1.3−/− in (E) and Cav1.3−/−/Cav3.1−/− in (F). (J) PR interval recorded in Cav1.3−/− and Cav1.3−/−/Cav3.1−/− mice during 24 h telemetric recording. Statistics: unpaired t test. (K) Number of 2nd-degree atrioventricular blocks per minutes (AVBII/min) in Cav1.3−/− and Cav1.3−/−/Cav3.1−/− mutant animals. Statistics: Mann-Whitney test. Error bars define the s.e.m.

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