Figure 5
Effect of tertiapin-Q on heart rate and atrioventricular conduction in HCN4-CNBD and Nav1.5+/− mice. (A) Representative samples of telemetric ECG recording HCN4-CNBD animals in absence (left) and in presence (right) of tertiapin-Q 5 mg/kg. Heart rate (B) and PR interval (C) in HCN4-CNBD mice before (filled light green circle) and after (horizontally green-striped circle) injection of 5 mg/kg tertiapin-Q. Statistics: paired t-test. (D) Values of the PR interval difference measured in tertiapin-Q 5 mg/kg and control (NaCl) condition in Nav1.5+/+ homozygous (Nav1.5+/+, black circle) and heterozygous (Nav1.5+/−, gray circle) mice. (E) PR intervals in Nav1.5+/+ mice in control condition (black circle) and in heterozygous mice injected with tertiapin-Q (horizontally gray-striped circle). (F) Values of the difference of QRS interval measured in tertiapin-Q 5 mg/kg and control (NaCl) condition in Nav1.5+/+ (black circle) and Nav1.5+/− (gray circle) mice. (G) QRS interval in Nav1.5+/+ mice in control condition (black circle) and in heterozygous Nav1.5+/− mice injected with tertiapin-Q (horizontally gray-striped circle). Statistics (D-G): unpaired t-test. *p < 0.05, **p < 0.01, ****p < 0.0001. Error bars define the s.e.m.
