Figure 7
Effect of different molecules employed to treat bradycardia and cardiac conduction dysfunctions in comparison to tertiapin-Q in Cav1.3−/− mice. Heart rate (A) and corresponding representative ECG traces (B) recorded in Cav1.3−/− animals before and after injection of 5 mg/kg tertiapin-Q, 0.5 mg/kg atropine (Atro), 0.1 mg/kg isoproterenol (Iso) or 10mg/kg theophylline (Theo). (C) Duration of effect on the heart rate of the different molecules injected in Cav1.3−/− mice. (D) PR interval values measured in control condition and after injection of 5 mg/kg tertiapin-Q, 0.5 mg/kg atropine, 0.1 mg/kg isoproterenol or 10 mg/kg theophylline. Legend: control condition (red bar); 5 mg/kg tertiapin-Q (horizontally red-striped bar); 0.5 mg/kg atropine (vertically red-striped bar); 0.1 mg/kg isoproterenol (red-dotted bar); 10 mg/kg theophylline (transversally red-striped bar). Statistics: Kruskal-Wallis test followed by multiple comparison Dunn’s test. *p < 0.05; **p < 0.01, ***p < 0.001, ****p < 0.0001. Error bars define the s.e.m.
