Figure 1
From: Asymmetry between Activators and Deactivators in Functional Protein Networks
(a) Schematic representation of a 2-activator 2-deactivator protein interaction network. Nodes represent proteins while edges represent interactions with other proteins. This network is fully connected, i.e., every protein interacts with every other protein via activation or deactivation. Arrows represent activation while bars represent deactivation. Edge width is proportional to the strength of interaction. This network represents the state of a 2-activator 2-deactivator system after 104 accepted mutations; this system was initially obtained by duplication of a 1-activator 1-deactivator network. (b) Amino-acid sequence to rate constant map depicting how 0s and 1s in the binary sequences interact to determine binding energies Eij. A 1:1 interaction produces an interaction energy equal to \(\varepsilon \). All other interactions contribute zero interaction energy.
