Figure 4
From: Asymmetry between Activators and Deactivators in Functional Protein Networks
Synergistic activation between activators versus competitive deactivation between deactivators. The activator (deactivator) phase is shown in red (blue), while \({k}_{{\text{A}}_{1},{\text{A}}_{2}}\) \(({k}_{{\text{D}}_{1},{\text{D}}_{2}})\) is shown in gray. +1 indicates Activator-1 (Deactivator-1) phase, while 0 indicates Activator-2 (Deactivator-2) phase. (a) The activation rate of an activator by the other activator, regardless of dominance or subdominance, does not correlate well with phase. (b) The deactivation rate of the subdominant deactivator is strongly correlated with the phase of the dominant deactivator.
