Table 3 EMPHASIS cohort. Association between LTL (T/S mean z-score) and seasonality.

From: Periconceptional environment predicts leukocyte telomere length in a cross-sectional study of 7–9 year old rural Gambian children

 

N

LRT χ2 (2 df)

LRT p-value

Model 1 – crude seasonality modelled with one pair of Fourier termsa Baseline: intercept only

218

8.27

0.016

Model 2 – adjusted for age and sex 1 pair Fourier terms + age + sex Baseline: age and sex only

218

7.89

0.019

Model 3 – adjusted for age, sex and estimated white cell composition 1 pair Fourier terms + age + sex + cell composition Baseline: age + sex + cell composition only

214

7.10

0.029

Model 4 – adjusted for age, sex and maternal BMI 1 pair Fourier terms + age + sex + maternal BMI Baseline: age + sex + maternal BMI only

218

7.96

0.019

Model 5 – adjusted for age + sex + birthweight 1 pair Fourier terms + age + sex + birthweight Baseline: age + sex + birthweight

200

6.51

0.039

  1. aIn each case, model fit is assessed by comparing the full and baseline models using a likelihood ratio test (LRT). LRT confirmed that two/three pairs of Fourier terms did not improve model fit. BMI, Body Mass Index.
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