Table 1 Associations of germline mutation rates with mortality in 122 Generation I individuals.

From: Germline mutation rates in young adults predict longevity and reproductive lifespan

 

Age-adjusted germline mutation rates

All-cause mortality

CVD mortality

Non-CVD mortality

HR (95% CI)

p

HR (95% CI)

p

HR (95% CI)

p

Both sexes

Continuous

1.28 (1.05, 1.56)

0.015

1.14 (0.87, 1.49)

0.355

1.49 (1.12, 2.00)

0.007

25th-50th percentile

1.51 (0.88, 2.59)

0.136

1.67 (0.79, 3.50)

0.177

1.41 (0.63, 3.14)

0.406

>50th-75th percentile

1.59 (0.94, 2.70)

0.087

1.29 (0.57, 2.91)

0.545

2.07 (1.01, 4.24)

0.047

> 75th percentile

2.07 (1.21, 3.56)

0.008

1.28 (0.56, 2.93)

0.559

3.24 (1.57, 6.68)

0.001

Trend test

1.25 (1.06, 1.48)

0.009

1.05 (0.82, 1.34)

0.694

1.48 (1.18, 1.87)

0.001

Males

Continuous

1.40 (1.04, 1.87)

0.025

1.39 (0.94, 2.07)

0.101

1.45 (0.94, 2.22)

0.092

25th-50th percentile

1.24 (0.58, 2.65)

0.578

1.62 (0.55, 4.76)

0.383

1.11 (0.37, 3.37)

0.849

>50th-75th percentile

1.80 (0.85, 3.83)

0.125

2.64 (0.86, 8.17)

0.091

1.45 (0.51, 4.14)

0.483

> 75th percentile

2.21 (1.03, 4.76)

0.043

2.39 (0.77, 7.46)

0.132

2.27 (0.79, 6.51)

0.126

Trend test

1.32 (1.03, 1.68)

0.026

1.35 (0.96, 1.90)

0.084

1.31 (0.93, 1.85)

0.122

Females

Continuous

1.22 (0.93, 1.59)

0.158

0.74 (0.49, 1.12)

0.152

1.76 (1.24, 2.51)

0.002

25th-50th percentile

2.04 (0.91, 4.59)

0.085

1.63 (0.56, 4.71)

0.368

2.17 (0.61, 7.64)

0.230

>50th-75th percentile

1.44 (0.67, 3.10)

0.350

0.43 (0.11, 1.69)

0.225

2.91 (1.06, 8.03)

0.039

> 75th percentile

1.97 (0.88, 4.38)

0.097

0.41 (0.10, 1.60)

0.199

5.16 (1.79, 14.93)

0.002

Trend test

1.18 (0.93, 1.50)

0.180

0.70 (0.47, 1.04)

0.081

1.68 (1.21, 2.33)

0.002

  1. Associations with mortality of age-adjusted mutation rates (AAMRs) treated as a continuous or categorical variable were analyzed in both sexes combined and in each sex separately. In each section (Both sexes, Males, and Females) the first row (Continuous) presents the effects on the Hazard Ratio (HR) of a one standard deviation increase in AAMRs. The second, third, and fourth rows present the mortality risks for subjects with increasing quartiles of AAMRs, expressed relative to the mortality risks for the lowest quartile (<25th percentile). The thresholds for the AAMRs are Males: 25% = −1.2385992, 50% = −0.1078028, 75% = 1.2402645; Females: 25% = −0.61610326, 50% = −0.09220471, 75% = 0.41736567. These thresholds were calculated using all 122 Generation I subjects. CI = Confidence Interval.
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