Table 3 Selected APD values from experimental and simulated action potentials in the control case and in the presence of the IKr blocker sotalol.
From: Computational translation of drug effects from animal experiments to human ventricular myocytes
Rabbit, control measured | Rabbit, drug measured | Human, control measured | Human, drug measured | Human, control model | Human, drug estimated based on rabbit data | |
|---|---|---|---|---|---|---|
APD50 (ms) | 162 | +21.2% (10 μM) | 185 (B) | +32.3% (30 μM) (B) | 221 | +24.7% (30 μM) |
+54.3% (52 μM) | 233 (O) | +20.6% (30 μM) (O) | ||||
APD90 (ms) | 194 | +19.6% (10 μM) | 235 (B) | +37.5% (30 μM) (B) | 317 | +28.8% (30 μM) |
+54.1% (52 μM) | 302 (O) | +28.2% (30 μM) (O) |
