Table 4 Parameter values of the Base model used to represent different species.
From: Computational translation of drug effects from animal experiments to human ventricular myocytes
Parameter | Human | Dog | Zebrafish | Rabbit | Guinea pig |
|---|---|---|---|---|---|
gKr (mS/μF) | 0.033 | 0.016 | 0.044 | 0.087 | 0.06 |
gCaL (nL/(μF ms)) | 0.17 | 0.077 | 0.086 | 0.25 | 0.21 |
gNa (mS/μF) | 5 | 1.4 | 2.2 | 2.3 | 0.90 |
gKs (mS/μF) | 0.003 | 0.1 | 0.0024 | 0.016 | 0.69 |
gKL (mS/μF) | 0.074 | 0.52 | 0.86 | 0.35 | 0.85 |
gto (mS/μF) | 0.54 | 0.31 | 0.0035 | 0.17 | 0.00 |
gNaL (mS/μF) | 0.025 | 0.0042 | 0.028 | 0.027 | 0.03 |
\({\bar{I}}_{{\rm{NaCa}}}\) (μA/μF) | 4.9 | 5.9 | 4.2 | 9.8 | 15.86 |
\({\bar{I}}_{{\rm{NaK}}}\) (μA/μF) | 1.8 | 1.4 | 9.2 | 2.8 | 1.62 |
gbCl (mS/μF) | 0.0056 | 0.00013 | 0.00087 | 0.011 | 0.00 |
gbCa (mS/μF) | 0.00055 | 0.00065 | 0.0019 | 0.0005 | 0.00 |
\({\bar{I}}_{{\rm{pCa}}}\) (μA/μF) | 0.068 | 0.58 | 0.056 | 0.064 | 0.60 |
gCaT (mS/μF) | 0 | 0 | 0.056 | 0 | 0 |
