Table 2 The most highly up- and down-regulated genes in hDFC induced to undergo osteoblastic differentiation.

From: Soluble silica stimulates osteogenic differentiation and gap junction communication in human dental follicle cells

Ensembl ID

Gene symbol

Gene name

Fold-change

p-value

Up-regulated genes

ENSG00000105664

COMP

cartilage oligomeric matrix protein

8.58

0.013

ENSG00000154556

SORBS2

sorbin and SH3 domain-containing 2

6.60

0.013

ENSG00000136160

EDNRB

endothelin receptor type B

6.43

0.013

ENSG00000117152

RGS4

regulator of G protein signalling 4

5.99

0.024

ENSG00000103888

KIAA1199

Cell migration inducing hyaluronidase 1

5.50

0.013

ENSG00000116741

RGS2

regulator of G protein signaling 2

5.23

0.013

ENSG00000196611

MMP1

matrix metalloproteinase 1

5.14

0.013

ENSG00000118113

MMP8

matrix metalloproteinase 8

5.02

0.031

ENSG00000159167

STC1

stanniocalcin-1

4.93

0.013

ENSG00000073756

PTGS2

prostaglandin-endoperoxide synthase 2

4.93

0.013

ENSG00000178919

FOXE1

forkhead box E1

3.26

0.038

ENSG00000166670

MMP10

matrix metalloproteinase10

3.04

0.013

ENSG00000103175

WFDC1

WAP four-disulfide core domain 1

2.68

0.038

ENSG00000137331

IER3

immediate early response 3

2.62

0.013

Down-regulated genes

ENSG00000128165

ADM2

adrenomedullin 2

−3.08

0.013

ENSG00000135069

PSAT1

phosphoserine aminotransferase 1

−3.66

0.013

ENSG00000204291

COL15A1

collagen type V alpha 1 chain

−6.89

0.013