Figure 5
From: Increased airway iron parameters and risk for exacerbation in COPD: an analysis from SPIROMICS
Higher BALF ferritin and iron levels are associated with increased exacerbation risk. (A,B) BALF ferritin (ng/mL) and BALF iron (µg/mL) in participants who had had one or more acute COPD exacerbation (n = 49 for ferritin, n = 48 for iron) when compared to participants who did not (n = 146). (C) Plasma ferritin levels in participants with (n = 30) versus without (n = 89) exacerbations. (A–C) median, 25th and 75th percentiles, extrema; Adjusted P values (age, sex, smoking status and site) (D–F) Predicted exacerbation rate per SPIROMICS bronchoscopy sub-study participant over 3–5 years of follow up by BALF ferritin (ng/mL) (D), BALF iron (µg/mL) (E) or plasma ferritin (ng/mL) (F) were estimated with a zero-inflated negative binomial model for a participant with a median FEV1 % predicted for (D) BALF ferritin (n = 195), (E) BALF iron (n = 194), and (F) plasma ferritin (n = 119).
