Table 1  Descriptive characteristics of both cohorts.

From: Resting state functional connectivity of the pain matrix and default mode network in irritable bowel syndrome: a graph theoretical analysis

 

healthy controls

IBS patients

p-value

Sendai cohort

n

29

30

 

age

22 [20–23]

21 [20–23]

0.56

sex (m/f)

15/14 (52/48%)

13/17 (43/57%)

0.52°

IBS-SSS GI symptoms

41 [12–80]

179.5 [139–203]

<0.0001

STAI trait anxiety

36 [33–40.5]

38.5 [31.5–45]

0.38

SDS depressive symptoms

35.5 [32.5–38]

35.5 [31–43.5]

0.73

VSI GI-specific anxiety

1 [0–5]

24.5 [13.5–33]

<0.0001

Gothenburg cohort

n

29

62

 

age

29 [26–33]

31 [26–39]

0.29

sex (m/f)

10/19 (34/66%)

17/45 (27/73%)

0.49°

IBS-SSS GI symptoms

12 [4–29]

295 [197–358]

<0.0001

IBS-SSS extracolonic symptoms

33.5 [15.5–52.5]

155.25 [100.5–223.0]

<0.0001

HADS anxiety symptoms

4 [1–5]

9 [6–12]

<0.0001

HADS depressive symptoms

1 [0–2]

5 [3–7]

<0.0001

VSI GI-specific anxiety

1 [0–2]

39 [24–51]

<0.0001

  1. Values are median [25th percentile-75th percentile] or n (%); p-values are from Kruskal-Wallis non-parametric one-way ANOVAs, except for ° from Pearson χ² test; italic indicates significant group differences.
  2. IBS, irritable bowel syndrome; IBS-SSS, IBS severity scoring system; STAI, Spielberger State-Trait Anxiety Inventory; SDS, Zung Self-rating Depression Scale; HADS, hospital anxiety & depression scale; VSI, visceral sensitivity index.
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