Figure 12

Late onset effect of chemotherapy on working (a–e) and reference (f) memory of mice in Morris water maze task. Chemotherapy did not affect working (a–e) and reference memory of mice (f). No differences were found between groups in daily escape latencies (a–d). Animals showed general improvement from day 1 to day 4 of the testing (e). Data are expressed as means + SEM. SHAM – sham operated mice, hGDX – mice with unilateral gonadectomy, CTRL – mice injected with saline, BEP – mice injected with three cycles of bleomycin, etoposide, and cisplatin, D1, D2, D3, D4 – the first, second, third and fourth day of testing. n = 15 mice for each group.