Figure 2

Locomotor activity in open field test. Application of chemotherapy led to lower locomotor activity as measured by total distance moved in both, SHAM and hGDX groups compared to CTRLs. Data are expressed as means + SEM. *p < 0.05. SHAM – sham operated mice, hGDX – mice with unilateral gonadectomy, CTRL – mice injected with saline, BEP – mice injected with three cycles of bleomycin, etoposide, and cisplatin. n = 15 mice for each group.