Scientific Reports

Table 3 Correlations between KOOS total score or magnitude of change in KOOS total score and the concentration or total amount of the 17 different humoral factors measured in PRPs.

From: Characteristics of autologous protein solution and leucocyte-poor platelet-rich plasma for the treatment of osteoarthritis of the knee

	KOOS total score								Magnitude of change in KOOS total score
	Concentration				Total amount				Concentration			Total amount
	pre	1 mo	3 mo	6 mo	pre	1 mo	3 mo	6 mo	1 mo	3 mo	6 mo	1 mo	3 mo	6 mo
IL-1α	− 0.244	−0.309	−0.595	−0.622	−0.048	0.073	−0.536	−0.483	−0.307	−0.629	−0.604	0.000	−0.705*	−0.536
IL-1β	− 0.168	−0.649*	0.281	0.231	−0.030	−0.553	0.192	0.233	−0.530	0.516	0.340	−0.674*	0.283	0.287
IL-1R2	− 0.194	−0.222	−0.192	−0.013	0.221	0.402	−0.212	0.186	−0.258	−0.096	0.038	0.070	−0.469	0.089
IL-1RA	− 0.080	−0.323	0.464	0.247	−0.058	−0.306	0.470	0.253	−0.133	0.689*	0.290	−0.144	0.679*	0.294
TNF-α	− 0.513	−0.634*	−0.268	−0.389	0.064	0.248	−0.371	−0.267	−0.362	0.069	−0.239	0.037	−0.550	−0.356
TNF-β	− 0.387	−0.080	−0.401	−0.504	0.084	0.466	−0.389	−0.208	0.329	−0.215	−0.372	0.381	−0.592*	−0.251
HGF	− 0.297	−0.515	0.030	−0.129	−0.125	−0.358	−0.182	−0.214	−0.436	0.288	−0.047	−0.601	−0.140	−0.241
PDGF	0.500	0.374	0.640*	0.094	0.581*	0.546	0.110	−0.007	−0.061	0.440	−0.158	−0.090	−0.338	−0.281
TIMP-1	− 0.144	−0.244	0.208	−0.223	0.159	0.153	−0.040	−0.250	−0.078	0.399	−0.152	−0.067	−0.186	−0.290
VEGF	− 0.075	−0.208	0.288	0.025	0.101	0.187	−0.007	−0.038	−0.145	0.449	0.024	0.091	−0.094	−0.093
FGF	0.481	0.296	0.245	0.340	0.430	0.422	−0.175	0.013	−0.178	−0.073	0.280	−0.071	−0.595*	−0.073
sTNF-R1	−0.338	−0.691*	0.200	−0.069	−0.018	−0.217	−0.211	−0.350	−0.469	0.550	0.032	−0.422	−0.268	−0.460
sTNF-R2	0.220	0.042	0.436	−0.164	0.330	0.241	−0.031	−0.298	−0.192	0.402	−0.378	−0.222	−0.318	−0.545
IL-6	− 0.353	−0.606*	−0.133	−0.099	−0.130	−0.335	−0.259	−0.119	−0.467	0.116	0.079	−0.465	−0.239	−0.021
sFAS	−0.453	−0.683*	−0.204	0.028	0.049	0.092	−0.407	0.007	−0.404	0.105	0.294	−0.077	−0.587*	0.051
TGF-β1	− 0.147	−0.309	−0.124	−0.174	0.098	0.037	−0.166	−0.077	−0.359	−0.043	−0.123	−0.221	−0.305	−0.121
MMP-3	− 0.398	−0.433	−0.007	0.096	0.006	0.295	−0.222	0.092	0.111	0.369	0.365	0.470	−0.286	0.189

The correlation coefficients (r) between the two parameters are shown in this table. *P < 0.05, **P < 0.01.
Correlations were analysed for scores before PRP treatment and those at 1, 3, and 6 months after PRP treatment.

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