Figure 6 | Scientific Reports

Figure 6

From: Phosphorylation of the Anaphase Promoting Complex activator FZR1/CDH1 is required for Meiosis II entry in mouse male germ cell

Figure 6

Sertoli cell-only phenotype appeared in aged Fzr19A/9A KI testes. (A) Hematoxylin and Eosin stained histological sections of seminiferous tubules in WT, Fzr1Gt wt/Gt wt, Fzr1+/9A and Fzr19A/9A KI mice at the indicated ages. Scale bar: 100 μm. (B) Hematoxylin and Eosin stained sections of the epididymis in WT, Fzr1Gt wt/Gt wt, Fzr1+/9A and Fzr19A/9A KI mice (35-week old). Scale bar: 100 μm. (C) Seminiferous tubule sections of indicated genotypes (5, 8 and 16-week-old) were stained for SOX9 (Sertoli cell marker), TRA98(germ cell marker) and DAPI. (D) Quantification of the seminiferous tubules of indicated genotypes (5, 8 and 16-week-old) that show Sertoli cell-only (SCO) phenotype per total tubules. n indicates the number of examined animals. **p < 0.01 (t-test). Scale bar: 25 μm.

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