Table 1 Summary of the differing aggregate types observed in this study. Identified iron phases and the presence of calcium and carbonate loading are shown for the cases where such measurements were obtained. “—” denotes not measured.
From: Iron stored in ferritin is chemically reduced in the presence of aggregating Aβ(1-42)
Sample Type | Incubation Time (hrs) | Aβ morphology | Iron Distribution | Iron oxidation state | Calcium Loading | Carbonate Loading |
|---|---|---|---|---|---|---|
Aβ(1-42) | All time points | Fibrillar | N/A | N/A | — | None |
Ferritin | All time points | N/A | N/A | Ferric (Fe3+) | — | None |
Aβ(1-42) +Ferritin | 0.5 | Fibrillar | Uniform throughout aggregate | Ferric (Fe3+) | — | — |
48 | Fibrillar | Uniform throughout aggregate | Ferric (Fe3+) | — | — | |
144 | Fibrillar | Uniform throughout aggregate | — | — | — | |
Amorphous | Localised deposits (sub micron) | Mixed Valence (Fe2+/Fe3+) | — | — | ||
240 | Fibrillar | Uniform throughout aggregate | Ferric (Fe3+) | Low | Low | |
Amorphous | Localised deposits (sub micron) | Mixed Valence (Fe2+/Fe3+)/Zero Valence (Fe0) | High | High |
