Figure 3
From: Prefrontal - subthalamic pathway supports action selection in a spatial working memory task
Intact behaviour in the elevated plus-maze during manipulations with the mPFC-ST pathway. (A) Experimental design, cross-frequency theta -> sub-theta detuning optogentic stimulation. Light was applied at the maze junction. (B) Time spend in the decision zone, (left panel, time on junction, p = 0.4, Mann-Whitney test), measures of activity (middle panel, junction entries, YFP: N = 8 mice, eNPAC: N = 8 mice, p = 0.9, t-test) and anxiety (right panel, entries to open arms, p = 0.4). (C) Experimental design, continuous optogentic inhibition at the maze junction. (D) Time on junction (p = 0.2, Mann-Whitney test) and other behavioral measures were not changed (p = 0.8 and p = 0.4 for left and right panels, respectively, t-test). Data are presented as mean ± SEM.
