Table 3 Univariate statistical analysis of fasting samples (Down syndrome (DS), n = 76; healthy control (CTRL), n = 35).

From: Plasma metabolome and cognitive skills in Down syndrome

Metabolites

DS (median)

CTRL (median)

DS/CTRL median

p-value

p-value after FDR Correction

Leucine

0.00361293

0.003694505

0.98

0.3591

0.4840

Isoleucine

0.00042202

0.000475091

0.89

0.1063

0.2059

Valine

0.00374662

0.003824309

0.98

0.5700

0.6796

Alanine

0.00483927

0.004903123

0.99

0.5277

0.6544

Acetate

0.00090934

0.000736206

1.24

0.0015

0.0137

Pyruvate

0.00226253

0.002109906

1.07

0.0085

0.0528

Acetone

0.00057523

0.000517008

1.11

0.1857

0.3199

Glutamine

0.00642759

0.006454857

1.00

0.8415

0.8696

Citrate

0.00042516

0.000385006

1.10

0.0996

0.2058

Glycine

0.00215948

0.002230915

0.97

0.6409

0.7358

Creatine

0.00114727

0.001000137

1.15

0.0018

0.0137

Creatinine

0.00045933

0.000489828

0.94

0.7342

0.7848

Lactate

0.00413212

0.003602912

1.15

0.0495

0.1395

Glucose

0.02830345

0.027789163

1.02

0.3054

0.4303

Mannose

0.00008250

8.55137E-05

0.96

0.6963

0.7709

Tyrosine

0.00060915

0.000681629

0.89

0.0166

0.0828

Histidine

0.00034121

0.000361783

0.94

0.0307

0.1030

Phenylalanine

0.00035893

0.000336898

1.07

0.4111

0.5311

Formate

0.00020937

0.00018

1.16

0.0187

0.0828

Fumarate

0.00001415

1.25068E-05

1.13

0.2377

0.3879

Threonine

0.00020752

0.000231226

0.90

0.0932

0.2058

Lysine

0.00049623

0.000488073

1.02

0.9873

0.9873

Acetatoacetate

0.00026706

0.000167242

1.60*

0.0265

0.1029

Methionine

0.00082180

0.000730695

1.12

0.0332

0.1030

unk1

0.00008045

8.6702E-05

0.93

0.0920

0.2058

unk2

0.00005625

4.58131E-05

1.23

0.0957

0.2058

unk3

0.00104660

0.000699813

1.50*

0.0000016

0.000025

3-hydroxybutyrate

0.00042926

0.000398342

1.08

0.2994

0.4303

Succinate

7.3119E-05

4.65665E-05

1.57*

0.0000001

0.0000035

2-hydroxybutyrate

0.00011189

7.75603E-05

1.44*

0.1753

0.3196

Proline

0.00025412

0.000230208

1.10

0.2878

0.4303

  1. The table contains the list of metabolites analyzed with NMR from samples taken from fasting patient. We reported both p-value of the univariate Wilcoxon test and p-value after FDR correction for each metabolite. Metabolites that show significant concentration differences in the two groups (p-value < 0.05) and/or show values in the interval next to 3:2 are reported in bold. *Values in the interval next to 3:2 (range 1.3–1.7).
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