Figure 3 | Scientific Reports

Figure 3

From: Efficient uptake and retention of iron oxide-based nanoparticles in HeLa cells leads to an effective intracellular delivery of doxorubicin

Figure 3

Internalization of IONP in HeLa cells. HeLa cells exposed to IONPCO for 16 h: (a) overview of the cell, scale = 2 µm; (b) magnification of the area marked with yellow square in (a); HeLa cells exposed to IONPDOX for 16 h: (c) overview of the whole cell, scale = 2 µm; (d) magnification of the area marked with red square in (c), scale = 200 nm. HeLa cells exposed to IONP for 16 h: (e) detail of macropinocytosis internalization of IONP, scale = 1 μm; (f) detail of endocytosis internalization of IONP, scale = 500 nm; (g) detail of lysosome entrapment of IONP, scale = 200 nm and (h) Quantity of internalized Fe3O4 in HeLa cells exposed to 0, respectively 100 ppm IONP during 16 h at 24 h after NP removal; data are presented as percentage of untreated control and are shown as mean ± SEM (n = 3).

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