Figure 2 | Scientific Reports

Figure 2

From: Hybrid PET/MRI enables high-spatial resolution, quantitative imaging of amyloid plaques in an Alzheimer’s disease mouse model

Figure 2The alternative text for this image may have been generated using AI.

PET-MR enables brain region specific quantification of [18F]-Florbetapir uptake. (A) Representative images of [18F]-Florbetapir uptake (coronal, horizontal, sagittal) for WT and 5xFAD mice by PET-MRI (top: MRI only, middle: PET + MRI, bottom: PET only). White represents highest uptake, blue represents zero uptake. Specific regions outlined: whole brain (blue), cortex (red), hippocampus (pink), thalamus (aqua), caudate (orange), cerebellum (yellow), brainstem (green). (B) Uptake was quantified within each region of the brain as percent injected dose / gram (%ID/g). 5xFAD mice had significantly greater uptake than WT mice in the cortex, hippocampus, caudate, thalamus and brainstem, but not the cerebellum (unpaired Student’s t-test, p = 0.0094, p = 0.0065, p = 0.0061, p = 0.0054, p = 0.0451, respectively; n = 6). (C) (left) Average [18F]-Florbetapir uptake in each brain region of 5xFAD mice normalized to average WT uptake. (right) Heatmap of %ID/g in each brain region normalized to %ID/g in muscle in forelimb (representative ROI in blue) in the same mouse. Images were analyzed using ASIpro software the Inveon Research Workplace (IRW) software (see Figure legend).

Back to article page