Table 1 Allele frequencies of the markers investigated in the different study populations (AFR, AMR, EAS, EUR, SAS, and NAT).

Gene	SNP, ID	Reference allele	Frequency in population:
Gene	SNP, ID	Reference allele	NAT	AFR	AMR	EAS	EUR	SAS
TPMT	rs1142345	T	0.873	0.933	0.942	0.978	0.971	0.982
TPMT	rs1800460	C	0.946	0.997	0.959	1	0.972	0.995
MTHFR	rs1801133	G	0.712	0.909	0.525	0.704	0.635	0.881
MTRR	rs1801394	A	0.903	0.754	0.719	0.737	0.477	0.475
MTHFD1	rs2236225	G	0.174	0.842	0.455	0.801	0.570	0.495
GGH	rs1800909	A	0.883	0.833	0.772	0.780	0.720	0.713
GGH	rs3758149	G	0.581	0.833	0.772	0.780	0.721	0.713
ATIC	rs4673993	T	0.323	0.905	0.693	0.706	0.686	0.509
ATIC	rs2372536	C	0.336	0.934	0.691	0.707	0.683	0.507
SLCO1B1	rs2306283	A	0.290	0.182	0.527	0.238	0.597	0.452
SLCO1B1	rs4149056	T	0.548	0.986	0.865	0.876	0.838	0.957
CCND1	rs9344	G	0.735	0.812	0.651	0.428	0.502	0.483

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