Figure 4

Alterations in differentially expressed genes (DEGs) after blast exposure. RNA-seq analysis from inner ear tissues demonstrated substantial differences in gene expression. (A) Volcano plots for the log2 (fold change) and − log10 (adjusted p value) of all DEGs in BOP1 vs SC1 at D1 post-blast, and (B) BOP2 vs SC2 at D28 post-blast, respectively. Statistical criteria for a gene to be considered differentially expressed were a fold-change ≥ 1.2 and an adjusted p value = 0.05. (C) Venn diagram depicting the distribution of the DEGs obtained from both acute (D1) and chronic (D28) phases. Seven genes are shared between D1 and D28.