Table 2 The relationship between miR-200b-3p expression levels in cancer tissues and clinicopathological factors of patients with HCC.

From: Decreased miR-200b-3p in cancer cells leads to angiogenesis in HCC by enhancing endothelial ERG expression

Characteristics

Number of patients

Percentage of patients (%)

miR-200b-3p/miR-191-5p (mean ± SD)

p value

Age (years)

0.344a

> 70

26

65

0.293 ± 0.323

≤ 70

14

35

0.218 ± 0.171

Gender

0.409b

Male

26

65

0.293 ± 0.235

Female

14

35

0.317 ± 0.352

Alcohol history

0.415b

Yes

19

47.5

0.228 ± 0.227

No

21

52.5

0.301 ± 0.321

Diabetes mellitus

0.185b

Yes

13

32.5

0.182 ± 0.209

No

27

67.5

0.308 ± 0.303

Performance status

0.219c

0

24

60

0.255 ± 0.247

1

11

27.5

0.203 ± 0.257

2

5

12.5

0.463 ± 0.431

Child Pugh score

0.124c

1

31

77.5

0.221 ± 0.231

2

3

7.5

0.511 ± 0.354

3

6

15

0.382 ± 0.417

Liver transferase (IU/L)

0.354b

Low (AST ≤ 30 or ALT ≤ 25)

17

42.5

0.223 ± 0.162

High (AST > 30 or ALT > 25)

23

57.5

0.299 ± 0.342

AFP (ng/mL)

0.176b

≤ 10

22

55

0.212 ± 0.223

> 10

18

45

0.333 ± 0.330

Platelets (× 104/µL)

0.346b

≤ 16

23

57.5

0.303 ± 0.309

> 16

17

42.5

0.218 ± 0.234

Prothrombin time (s)

0.302b

≤ 13

32

80

0.244 ± 0.249

> 13

8

20

0.359 ± 0.385

Viral infection

0.245a

Yes

29

72.5

0.289 ± 0.319

No

11

27.5

0.208 ± 0.117

Diameter (cm)

0.899b

≤ 2

17

42.5

0.260 ± 0.312

> 2

23

57.5

0.272 ± 0.260

Multiplicity

0.082b

Yes

5

12.5

0.470 ± 0.311

No

35

87.5

0.238 ± 0.267

Differentiation

0.447c

Well

10

25

0.358 ± 0.375

Moderate

26

65

0.246 ± 0.250

Poor

4

10

0.173 ± 0.174

Pattern

0.401c

Trabecular

21

52.5

0.314 ± 0.312

Solid

2

5

0.087 ± 0.097

Pseudoglandular

3

7.5

0.064 ± 0.053

Mixed

14

35

0.264 ± 0.256

Differentiation in trabecular

0.081b

Well

7

33.3

0.482 ± 0.387

Moderate + poor

14

66.7

0.230 ± 0.240

Grade in mixed

0.352b

Well

2

14.3

0.101 ± 0.043

Moderate + poor

12

85.7

0.291 ± 0.268

Microvascular invasion

0.512a

Yes

6

15

0.437 ± 0.437

No

34

85

0.247 ± 0.247

Cirrhosis

0.381b

Yes

16

40

0.315 ± 0.340

No

24

60

0.235 ± 0.233

TNM stage

0.511b

I

29

72.5

0.248 ± 0.276

II

11

27.5

0.315 ± 0.295

BCLC stage

0.540d

0

4

10

0.204 ± 0.095

A

16

40

0.257 ± 0.270

B

1

2.5

0.682 ± 0.000

C

13

32.5

0.212 ± 0.250

D

6

15

0.382 ± 0.417

  1. AFP, α-fetoprotein, BCLC Barcelona Clinic Liver Cancer.
  2. Statistical analyses: aunpaired t test with Welch's correction, bunpaired t test, cone-way analysis of variance, dKruskal–Wallis test.