Figure 5
Liver transplantation appears to have a beneficial effect on growth of 19 individuals with UCDs. Individuals with UCDs (n = 19) have normal weight gain (A) over time pre- and post-transplantation (p = 0.48; LME ANOVA), but suffer from impaired growth (B) prior to transplantation [mean z-score at first observation: 0.53, mean z-sore at last observation prior to LTx: − 0.75; p < 0.001; contrast t-test). However, growth retardation does not further aggravate after transplantation (mean z-score at last observation prior to LTx: − 0.75, mean z-score at last observation after LTx: − 0.17; p = 0.13; contrast t-test). Data are shown as median (black line) and mean (triangle), length of the box corresponds to IQR, upper and lower whiskers correspond to max. 1.5 × IQR, each point represents an outlier. Descriptive characteristics are presented separately in Supplementary Table S1. LTx, liver transplantation.
