Figure 3 | Scientific Reports

Figure 3

From: Inhalation exposure to cigarette smoke and inflammatory agents induces epigenetic changes in the lung

Figure 3

DNA hydroxymethylation changes in lung DNA of female A/J mice exposed to ECS for 10 weeks with or without aspirin co-treatment. (a) Global 5hmC levels as determined by isotope dilution HPLC–ESI–MS/MS. The values shown are mean ± standard deviation (N = 5). (b) Violin plots of hydroxymethylation fraction of all assayed CpG sites in gene bodies and promoters determined by RRBS/oxRRBS. Differential hydroxymethylation data was subjected to Ingenuity Pathway Analysis (IPA). (c) Top diseases and disorders associated with hydroxymethylation changes. (d) Top molecular and cellular functions associated with hydroxymethylation changes. (e) Top upstream regulators associated with hydroxymethylation changes.

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