Table 1 Single nucleotide polymorphisms (SNPs) detected in Pmdhfr, Pmdhps and Pmmdr1 genes, and their downstream effects.
Gene | Position | Ref | SNP1 | Effect | Change in codon | Change in amino acid | Proportion of SNP1 | SNP 2 | Effect | Change in codon | Change in amino acid | Proportion of SNP2 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Pmdhfr | 1,292,023* | C | A | NS | ttC/ttA | F57L* | 0.17 | G | NS | ttC/ttG | F57L* | 0.11 |
1,292,026* | A | G | S | agA/agG | R58 | 0.28 | C | NS | agA/agC | R58S* | 0.67 | |
1,292,193* | A | G | NS | aAc/aGc | N114S* | 0.78 | / | / | / | / | ||
Pmdhps | 1,657,704 | C | T | NS | Gtg/Atg | V121M | 0.06 | / | / | / | / | |
1,657,993 | C | T | I | / | / | 0.28 | / | / | / | / | ||
1,658,014 | A | G | I | / | / | 0.11 | / | / | / | / | ||
1,658,019 | A | T | I | / | / | 0.22 | C | I | / | / | 0.06 | |
1,658,049 | T | A | I | / | / | 0.06 | / | / | / | / | ||
Pmmdr1 | 525,728* | T | G | NS | ttA/ttC | L1063F* | 0.11 | / | / | / | / | |
527,072 | C | T | S | ttG/ttA | L615 | 0.22 | / | / | / | / | ||
527,449 | G | T | NS | Ctt/Att | L490I | 0.06 | / | / | / | / | ||
527,528 | G | A | S | agC/agT | S463 | 0.33 | / | / | / | / |
