Figure 2
Research methodology for the study—16 plant species were identified in close collaboration with the traditional healers of the Greater Mpigi region based on the species’ traditional use in treatment of infections. After collecting specimens and producing a medicinal plant extract library, our in vitro study commenced, targeting bacterial virulence and growth of multidrug-resistant ESKAPE pathogens. After initial growth inhibition, quorum quenching and cytotoxicity library screenings, hits were followed up via dose–response studies, a δ-toxin production inhibition assay and chemical characterization. Results of this study will ultimately be transferred back to the traditional healers through field workshops.
