Table 1 Characteristics of studies included in the meta-analysis.

From: HLA genotypes and cold medicine-induced Stevens–Johnson syndrome/toxic epidermal necrolysis with severe ocular complications: a systematic review and meta-analysis

Author (year)

Study design

Participant ethnicity

Number of participant

HLA genotypes

Case (n)

Control (n)

HLA-A genotypes

HLA-B genotypes

HLA-C genotypes

Ueta et al. (2014)23

Case control

Japanese

151

(Group1 KPUM: n = 131; Group2 NIHS: n = 20)

639

(Group1 KPUM: n = 419; Group2 NIHS: n = 220)

HLA-A*0206, HLA-A*0301,

HLA-A*1101, HLA-A*2402

HLA-B*1301, HLA-B*1501,

HLA-B*4402, HLA-B*4403,

HLA-B*4601, HLA-B*5201, HLA-B*5401

HLA-C*0304, HLA-C*0501,

HLA-C*1202

Ueta et al. (2014)24

Case control

Indian

20

55

HLA-A*0206

HLA-B* 4403

HLA-C*0701

Brazilian

39

(Ethnicity: Pardo, n = 19; White, n = 15; Black, n = 3; White/Indian, n = 1; White/Black/Indian, n = 1)

134

(Ethnicity: Pardo, n = 66; White, n = 62; Black, n = 4, Indian/White, n = 2)

Korean

31

90

Kannabiran et al. (2017)33

Case control

Indian

80

50

HLA-A*0101, HLA-A*0211,

HLA-A*0301, HLA-A*1101,

HLA-A*2402,HLA-A*2601, HLA-A*3201,HLA-A*3303, HLA-A*6801

HLA-B*0705, HLA-B*1502,

HLA-B*3501, HLA-B*3503,

HLA-B*4006, HLA-B*4403,

HLA-B*5101, HLA-B*5201,

HLA-B*5701

HLA-C*0102, HLA-C*0401,

HLA-C*0602, HLA-C*0701,

HLA-C*0702, HLA-C*0801,

HLA-C*1202, HLA-C*1502

Wakamatsu et al. (2017)34

Case control

Brazilian

39

(Ethnicity: European, n = 16; Pardoa, n = 19)

133

(Ethnicity: European, n = 61; Pardo, n = 66)

HLA-A*0101, HLA-A*0201,

HLA-A*0202, HLA-A*0205,

HLA-A*0206, HLA-A*0301,

HLA-A*1101, HLA-A*2402,

HLA-A*2601, HLA-A*2902,

HLA-A*3001, HLA-A*3002,

HLA-A*3101, HLA-A*3201, HLA-A*3303, HLA-A*3402,

HLA-A*3601,HLA-A*6601,

HLA-A*6801,HLA-A*6802,

HLA-A*7401

HLA-B*0702, HLA-B*0801,

HLA-B*1302, HLA-B*1401, HLA-B*1510, HLA-B*1801,

HLA-B*2705, HLA-B*3501,

HLA-B*3502, HLA-B*3503,

HLA-B*3508, HLA-B*3801,

HLA-B*3903, HLA-B*4001, HLA-B*4002, HLA-B*4101,

HLA-B*4201, HLA-B*4402,

HLA-B*4405, HLA-B*4901,

HLA-B*5001,HLA-B*5101,

HLA-B*5201,HLA-B*5301,

HLA-B*5501,HLA-B*5601,

HLA-B*5701,HLA-B*5703,

HLA-B*5801,HLA-B*5803

HLA-C*0102, HLA-C*0202,

HLA-C*0302, HLA-C*0303,

HLA-C*0304, HLA-C*1203,

HLA-C*0401, HLA-C*0501,

HLA-C*0602, HLA-C*0701,

HLA-C*0702, HLA-C*0704,

HLA-C*0802, HLA-C*1203,

HLA-C*1402, HLA-C*1502,

HLA-C*1601, HLA-C*1701

Jongkhajornpong et al. (2018)35

Case control

Thai

71

119

HLA-A*2402, HLA-A*3303

HLA-B*2704, HLA-B*4401,

HLA-B*4403

HLA-C*0701

Jun et al. (2019)36

Case control

Korean

40

120

HLA-A*0206

 

HLA-C*0304, HLA-C*0503

  1. HLA human leukocyte antigen, KPUM Kyoto Prefectural University of Medicine, NIHS National Institute of Health Science.
  2. aPardo is a commonly used term to refer to Brazilians of mixed ethnic ancestries, typically white Brazilians and Afro-Brazilians.