Figure 4
Electron micrographs of a WT NMJ (A) and NMJs from a 2 week post-tSC ablation animal (B–E). (A) Young adult WT mouse NMJ. Asterisk denotes post-synaptic muscle fiber and thin arrow denotes overlying tSC. (B) A portion of the axon terminal is without tSC coverage (thick arrow). (C) Terminal Schwann cell process completely separates axon terminal from post-synaptic gutter (thick arrow). (D) Terminal Schwann cell process partially separating axon terminal from post-synaptic gutter (thick arrow). (E) Terminal Schwann cell phagocytosing a piece of axon terminal (thin arrow) and another process separating the axon from the secondary folds (thick arrow). All panels are from different NMJs, except for B and E, which are different parts of the same NMJ. The dark appearance of the secondary folds in B–E are an artefact and not the result of specific staining. Microsoft Powerpoint was used to generate this figure. Scale bar 500 nm, applies for all panels.
