Figure 1

The alternative GWAS’s analysis strategy. ADNI-1 and ADNI-2 datasets were analyzed unimputed at the SNP, Gene and Pathway levels using three machine learning methods [i.e., l1l2FS within PALLADIO framework, SKAT and Group Lasso with overlap (w. o.)]. The global signature represents the summary of the single integrated signatures identified within the proposed GWAS strategy.