Table 1 A summary of chondrocyte subtypes with key expressed genes and involved pathways.
From: Synovial cell cross-talk with cartilage plays a major role in the pathogenesis of osteoarthritis
Cell type | Key genes | Key involved pathways | False discovery rate |
|---|---|---|---|
Homeostatic chondrocyte (HomC) | MMP3, FOSB, JUN | Regulation of gene expression | 1.35E−09 |
Response to external stimulus | 1.06E−09 | ||
Hypertrophic chondrocyte (HTC) | COL10A1, IBSP, JUN | System development | 9.90E−09 |
Multicellular organismal development | 3.89E−08 | ||
Pre-hypertrophic chondrocyte (preHTC) | COL10A1, IBSP, COL2A1 | System development | 5.50E−09 |
Skeletal system development | 6.63E−08 | ||
Reparative chondrocyte (RepC) | COL2A1, CILP, COL3A1, COMP | Extracellular matrix organization | 3.98E−10 |
Collagen fibril organization | 1.41E−06 | ||
Pre-Fibrochondrocyte (preFC) | IL11, COL2A1, CILP, OGN | Extracellular matrix organization | 5.28E−22 |
Extracellular matrix disassembly | 1.34E−08 | ||
Fibrochondrocyte (FC) | COL1A1, COL1A2, S100A4, PRG4 | Extracellular matrix organization | 1.27E−33 |
Movement of cell or subcellular component | 7.94E−17 | ||
Regulatory chondrocyte (RegC) | CHI3L1, CHI3L2 | Negative regulation of biological process | 1.12E−04 |
Cellular response to metal ion | 1.32E−06 |
