Figure 1

Distribution of BCL2 fluorescence intensities of tumor cells. (A, D) Representative images of various BCL2 fluorescence intensities regardless of the proportion of immuno-stained tumor cells are shown. The BCL2 fluorescence signal is pseudocolored in green. (E, F) The BCL2 fluorescence intensities of CD20-positive tumor cells were classified into 4 quantile groups regardless of the case. Subsequently, the mean value of pixel fluorescence intensity per each tumor cell is plotted on a single cell level in a representative core (the inset shows immunofluorescent stained image of the corresponding core) (E). The proportion of the cells corresponding to each quantile group is plotted on a case-by-case basis (F).