Table 1 Baseline characteristics of patients with diffuse large B-cell lymphoma in the training set.
Characteristics | Total n = 221 (%) | BCL2 AQUA score | MYC AQUA score | ||||
|---|---|---|---|---|---|---|---|
Low n = 135 (%) | High n = 86 (%) | p value | n = 166 (%) | n = 55 (%) | p value | ||
Age > 60 years | 98 (44.3) | 58 (43.0) | 40 (46.5) | 0.605 | 62 (37.3) | 36 (65.5) | 0.0003 |
Sex, male | 126 (57.0) | 77 (57.0) | 49 (57.0) | 0.9930 | 97 (58.4) | 29 (52.7) | 0.4588 |
LDH > normal | 101 (45.7) | 59 (43.7) | 42 (48.8) | 0.455 | 67 (40.4) | 34 (61.8) | 0.0056 |
B symptoms+ | 58/219 (26.5) | 29/133 (21.8) | 29 (33.7) | 0.0510 | 42/165 (25.5) | 16/54 (29.6) | 0.5462 |
NA (2) | NA (2) | NA (1) | NA (1) | ||||
Hb < normal | 109 (49.3) | 61 (45.2) | 48 (55.8) | 0.1233 | 79 (47.6) | 30 (54.5) | 0.3712 |
Stage 3–4 | 126 (57.0) | 74 (54.8) | 52 (60.5) | 0.408 | 93 (56.0) | 33 (60.0) | 0.6057 |
IPI 3–5 | 81 (36.7) | 44 (32.6) | 37 (43.0) | 0.1167 | 56 (33.7) | 25 (45.5) | 0.1180 |
BM involvement | 45/220 (20.5) | 28 (20.7) | 17/85 (20.0) | 0.895 | 34 (20.5) | 11/54 (20.4) | 0.9859 |
NA (1) | NA (1) | NA (1) | |||||
CR | 195 (88.2) | 126 (93.3) | 69 (82.2) | 0.003 | 154 (92.8) | 41 (74.5) | 0.0003 |
2-years EFS rate (%) | 70.34 | 80.93 | 54.04 | 75.36 | 55.02 | ||
Non-GCB type | 142/207 (68.6) | 78/126 (61.9) | 64/81 (79.0) | 0.01 | 106/156 (67.9) | 36/51 (70.6) | 0.7244 |
NA (14) | NA (9) | NA (5) | NA (10) | NA (4) | |||
