Figure 4
(a) Network containing potential oncogenic lncRNAs that could be master regulators of 91 cell cycle genes. High expression of the 5 potential oncogenic lnRNAs (G073851, PTTG3P, RACGAP1P, GSE61474_XLOC_040880 and CTD-2267D19.6) and 85/91 mRNAs are associated with poor differentiation of tumor. High expression of 3/5 potential oncogenic lncRNAs (RACGAP1P, GSE61474_XLOC_040880 and CTD-2267D19.6) are associated with incomplete tumor capsule. Oval shape: lncRNAs; Square: mRNAs; black lines: Strong correlation. Outline of oval and square represents lncRNAs/mRNAs expression in T versus NT; red: upregulation; colours within oval/square represents the clinical significance of lncRNAs/mRNAs. Blue background: Edmondson Grade; yellow background: tumor capsule (includes encapsulation and degree of encapsulation); *: clinical significance with FDR < 0.05. The network was drawn using Cytoscape software (Version 3.5.1) (https://cytoscape.org/). (b) Pathways of the 91 strongly correlated genes. (c–g) Boxplots show expression of lncRNAs in adjacent non-tumor, lower grade tumor and higher grade tumor. (h–j) Boxplots show expression of lncRNAs in adjacent non-tumor, tumor with capsule and tumor without capsule.
