Figure 6
(a) Network containing potential tumor suppressing lncRNAs that could be master regulators of 8 metallothionein genes. Low expression of the 4 potential tumor suppressing lnRNAs (MT1DP isoforms (NR_027781 and NR_003658)) and MT1IP isoforms (NR_003669 and NR_104046)) and 7 mRNAs are associated with tumor invasion. Oval shape: lncRNAs; Square: mRNAs; Black lines: Strong correlation. Outline of oval and square represents lncRNAs/mRNAs expression in T versus NT; green: downregulation; colours within oval/square represents the clinical significance of lncRNAs/mRNAs. Green background: Tumor invasion. The network was drawn using Cytoscape software (Version 3.5.1) (https://cytoscape.org/). (b) Pathways of the 8 strongly correlated genes. (c–f) Boxplots show expression of lncRNAs in adjacent non-tumor, tumor without invasion and tumor with invasion.
