Figure 1 | Scientific Reports

Figure 1

From: Bax and Bak jointly control survival and dampen the early unfolded protein response in pancreatic β-cells under glucolipotoxic stress

Figure 1

Combined and individual knockout of Bax and Bak in pancreatic islets. (a) Relative Bax and (b) relative Bak mRNA levels after tamoxifen administration and Cre recombination in islets from Bax SKO (Baxflox/flox:Bak+/+:Cre+), Bak SKO (Baxflox/flox:Bak−/−), and Bax-Bak DKO (Baxflox/flox:Bak−/−:Cre+) mice compared to WT (Baxflox/flox:Bak+/+) islets. (n = 4–6 animals of each genotype; islets isolated from 12 to 16 week old mice 1-week post-tamoxifen administration). Data are normalized to WT and represent mean ± SEM. Statistical comparisons were done using 1-way ANOVA with Bonferroni post-hoc tests. ***p < 0.001 compared to WT; N.D. not detected.

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