Figure 2 | Scientific Reports

Figure 2

From: ULK1 and ULK2 are less redundant than previously thought: computational analysis uncovers distinct regulation and functions of these autophagy induction proteins

Figure 2

Alignment of kinase domains of the yeast Atg1 protein and its human homologs. (a) Based on multiple sequence alignment of the kinase domains ULK1 and ULK2 are the most similar to each other (similar results were obtained with multiple sequence alignment of the complete amino-acid sequences shown on Supplementary Figure S1). The protein sequences were downloaded from Uniprot (https://uniprot.org/)50 and the protein alignments were carried out with MUSCLE (https://ebi.ac.uk/Tools/msa/muscle/)51; (b) Unique motifs shown on ULK1 and ULK2 proteins; (c) Superimposition of 3D structures of ULK1 (purple) and ULK2 (orange) kinase domains shows aligning and non-aligning parts. 3D structure alignment was carried out with UCSF Chimera software48.

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