Table 2 ULK2-specific motif details from the ELM resource (https://elm.eu.org/)52.
ULK2-specific motif name | Functional site class | Function |
|---|---|---|
DOC_MAPK_DCC_7 | MAPK docking motifs | Interaction towards the ERK1/2 and p38 subfamilies of MAP kinases, regulators of cellular signalling |
LIG_APCC_ABBA_1 | APCC activator-binding ABBA motif | Regulation of APC/C activity in ubiquitination for proteasome-dependent degradation in a cycle-dependent manner |
LIG_CaM_IQ_9 | Helical calmodulin binding motifs | Primary receptor of intracellular Ca2 + capable of responding to a wide range of calcium concentration and translates the Ca2 + -signal into cellular processes |
LIG_EF_ALG2_ABM_2 | ALG-2 EF hand ligand | Binding to ALG-2 protein in a Ca2 + -dependent manner. ALG-2 has been implicated in ER-stress-induced apoptosis, cell cycle progression, the endosomal pathway, and cancer |
LIG_SH2_GRB2like | Phosphotyrosine ligands bound by SH2 domains | Binding to specific motifs containing a phosphorylated tyrosine residue, propagating the signal downstream promoting protein–protein interaction and/or modifying enzymatic activities |
LIG_TRAF6 | TRAF6 binding site | Initiation of intracellular signalling caused by members of the tumor necrosis factor receptor (TNFR) superfamily, and direct interaction with intracellular regions of various TNF cytokine receptors |
LIG_WW_1 | WW domain ligands | Recognition of proteins that contain the motif PPXY, being involved in many cellular processes such as ubiquitin-mediated protein degradation and mitotic regulation and several human diseases |
