Table 6 Association of BMI with metabolic variables and SNPs (dominant model).

p p	rs1941404 NNMT NS NS	Glucose NS < 0.05	HDL-c 0.05 0.0001	Triglycerides 0.05 < 0.001	Acyl-Ghrelin (pg/mL) < 0.01 < 0.01	Leptin (ng/mL) < 0.0001 < 0.0001	Insulin (µIU/mL) NS < 0.0001	HOMA-IR NS < 0.0001	MNA-1 (pg/mL) < 0.05 < 0.001	REE (Kcal/day) < 0.0001 < 0.0001
p p	rs1421085 FTO NS 0.01	Glucose NS < 0.05	HDL-c < 0.05 < 0.001	Triglycerides NS < 0.001	Acyl-Ghrelin (pg/mL) < 0.01 < 0.01	Leptin (ng/mL) < 0.0001 < 0.0001	Insulin (µIU/mL) NS < 0.0001	HOMA-IR NS < 0.0001	MNA-1 (pg/mL) 0.05 < 0.001	REE (Kcal/day) < 0.0001 < 0.0001

Multivariate p in first line; univariate fit p in the second line; BMI = body mass index, HDL = high-density lipoproteins, HOMA-IR = Homeostasis model.
assessment insulin resistance, LDL = low-density lipoproteins, MNA-1 = N¹-methylnicotinamide, REE = resting energy expenditure, * = mg/dL. Multiple.
regression analysis adjusted by gender and age. Model including rs1941404 NNMT explained 0.53 of the variability. Model including rs1421085 FTO.
explained 0.72 of the variability.

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