Figure 4
From: Association study based on topological constraints of protein–protein interaction networks
A weighted human disease network (HDN) generated by NetPAS. (a) The association Z-score heatmap of 19 diseases, which include 13 cancers (grey), 3 mental disorders (orange) and three other diseases (red). (b) A weighted human disorder network constructed from the Z-score matrix indicates that most cancers highly interacted with each other. Some mental disorders including Schizophrenia and Major depression disorder (MDD) are associated with certain cancers, and Type II Diabetes (Diabetes2) is associated with ovarian cancer. Note that in this wHDN all interactions are positive, and no negative or suppressed interactions among these diseases (i.e., Z < − 2) have been observed.
