Figure 5
From: Association study based on topological constraints of protein–protein interaction networks
An example of GO and pathway enrichment performed by NetPAS using the hallmark set HALLMARK_OXIDATIVE_PHOSPHORYLATION. (a) The Top ten enriched gene ontology terms, including biological process (BP), cellular component (CC) and molecular function (MF) (left), and enriched KEGG pathway terms (right) using NetPAS (left) and DAVID (right). The magnitude of enrichments is scaled by the colors from white (Z = 0) to red (Z = Zmax). The p-values estimated by DAVID were converted to Z-scores using a two-tailed normal distribution for coloring. (b) Interaction sub-network between the target gene (red nodes) and the genes affiliated with the top 10 biology process (BP) GO terms (blue nodes); the genes that are both affiliated with the functional term and belong to the target gene set are shown in yellow nodes. Formulas used for calculating the Z-scores for each BP term are written on top of each subnetwork.
