Table 1 Cytokine levels (pg/mL) in serum from mice with staphylococcal septic arthritis.

From: Tofacitinib treatment aggravates Staphylococcus aureus septic arthritis, but attenuates sepsis and enterotoxin induced shock in mice

 

IL-6

TNF-α

IFN-γ

MCP-1

RANKL

Tofacitinib

132.9 ± 19.4†

222.5 ± 122.1

12.3 ± 2.1

112.8 ± 35.5

340.5 ± 135.9

Controls

48.9 ± 9.4

159.7 ± 55.8

9.6 ± 1.6

73.5 ± 17.7

379.8 ± 80.71

  1. NMRI mice treated with tofacitinib (n = 8) or vehicle only as control (n = 9) were inoculated with an arthritogenic dose of S. aureus Newman (8.9 × 106 CFU/mouse). Mice were sacrificed on day 10 and serum was collected and analyzed for cytokines. All values are pg/mL. Data were shown as mean ± SEM. †p = 0.0003 versus control group by Mann–Whitney U test.
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