Figure 1
From: Maternal glucose homeostasis is impaired in mouse models of gestational cholestasis
Glucose tolerance and insulin sensitivity is impaired in control and cholic acid-fed pregnant mice. Mice were fed cholic acid (CA)-supplemented diet from D1 of pregnancy until euthanisation at D18 (or equivalent for non-pregnant controls). a Glucose tolerance tests (GTT) were performed at D18 (or equivalent for non-pregnant controls). D0 chow, n = 9; D18 chow, n = 6; D0 CA, n = 8; D18 CA, n = 6. b Insulin tolerance tests (ITT). D0 chow, n = 6; D18 chow, n = 7; D0 CA, n = 6; D18 CA, n = 6. c Plasma insulin concentrations after glucose challenge. n = 6 for all groups. p < 0.05 as determined by repeated-measures two-way ANOVA followed by Bonferroni’s post-hoc test: aD0 chow v D18 chow, bD0 CA v D18 CA, cD0 chow v D0 CA.
