Figure 4

Fecal bile acids (BA) are reduced in Fxr^−/− mice. Bile acids were measured in feces from pregnant (D18) and non-pregnant (D0) wild type (WT) and Fxr^−/− mice. a mRNA expression of Fgf15 in the distal ileum. D0 WT, n = 10; D18 WT, n = 6; D0 Fxr^−/−, n = 7, D18 Fxr^−/−, n = 8. b Total bile acids. c Total primary bile acids. d Total secondary bile acids. e Individual bile acid species. D0 WT, n = 6; D18 WT, n = 8; D0 Fxr^−/−, n = 7, D18 Fxr^−/−, n = 8. p < 0.05 for the following comparisons: ^a vs D0 WT, ^b vs D18 WT, ^c vs D0 Fxr^−/−.