Figure 5

Tgr5 deficiency impairs glucose tolerance and insulin secretion during pregnancy. Glucose metabolism was assessed in Tgr5^−/− mice and wild type (WT) littermate controls. a Glucose tolerance tests (GTT) were performed in non-pregnant (D0) and pregnant (D18) mice. D0 WT, n = 6; D18 WT, n = 5; D0 Tgr5^−/−, n = 7; D18 Tgr5^−/−, n = 8. b Plasma insulin concentrations after oral glucose tolerance test (OGTT; 2 g/kg body weight). D0 WT, n = 4; D18 WT, n = 5; D0 Tgr5^−/−, n = 4; D18 Tgr5^−/−, n = 9. p < 0.05 as determined by repeated-measures two-way ANOVA followed by Bonferroni’s post-hoc test, for the following comparisons: ^a D0 WT vs D18 WT, ^b D0 Tgr5^−/− vs D18 Tgr5^−/−, ^c D18 WT vs D18 Tgr5^−/−.